Dolasetronum [Inn-Latin]
Brand names,
Dolasetronum [Inn-Latin]
Analogs
Dolasetronum [Inn-Latin]
Brand Names Mixture
Dolasetronum [Inn-Latin]
Chemical_Formula
C19H20N2O3
Dolasetronum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic2/dolaset.htm
Dolasetronum [Inn-Latin]
fda sheet
Dolasetronum [Inn-Latin]
msds (material safety sheet)
Dolasetronum [Inn-Latin]
Synthesis Reference
M. W. Gittos, Eur. pat. Appl. 266,730 (1988 to Merrell Dow).
Dolasetronum [Inn-Latin]
Molecular Weight
324.374 g/mol
Dolasetronum [Inn-Latin]
Melting Point
278 oC
Dolasetronum [Inn-Latin]
H2O Solubility
Freely soluble in water
Dolasetronum [Inn-Latin]
State
Solid
Dolasetronum [Inn-Latin]
LogP
2.347
Dolasetronum [Inn-Latin]
Dosage Forms
Intravenous injection; Tablet
Dolasetronum [Inn-Latin]
Indication
For the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy, including initial and repeat courses and prevention of postoperative nausea and vomiting
Dolasetronum [Inn-Latin]
Pharmacology
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
Dolasetronum [Inn-Latin]
Absorption
Orally-administered dolasetron is well absorbed
Dolasetronum [Inn-Latin]
side effects and Toxicity
No information avaliable
Dolasetronum [Inn-Latin]
Patient Information
Dolasetronum [Inn-Latin]
Organisms Affected
Humans and other mammals